Space Exploration has its own resource generator code that is different from vanilla Factorio. Resource patches in Space Exploration do not grow substantially larger (in size and richness) the farther away they are from map origin. Some resources are also restricted to spawn only on ground surfaces (e.g. crude oil) or space surfaces (e.g. methane ice). Some resources are even restricted by biome—cryonite ore, for example, can only spawn in the ice biome.
SE resource generation code might result in incompatibility with any other mod that manipulates resource generation, including Resource Spawner Overhaul or any mod that yields infinite resources.